DXN Cordyceps Tablet

DXN Cordyceps Tablet

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Cordyceps sinensis,
the Cordyceps species most widely used as a dietary supplement,
naturally grows on the back of the larvae of a caterpillar from the moth
Hepialus armoricanus Oberthur found mainly in China, Nepal, and
Tibet. The mycelium invades the caterpillar 
and eventually
replaces the host tissue. The stroma (fungal fruit body) grows out of the
top of the caterpillar. The remaining structures of the caterpillar along with
the fungus are dried and sold as the dietary supplement cordyceps.

Commonly known as “dong chong xia cao” (summer-plant, winter-worm)
in Chinese, cordyceps has been used as a tonic food in China and Tibet and has been
used as a food supplement and tonic beverage among the rich because of its
short supply due to over harvesting. It is also an ingredient in soups and
other foods used traditionally in Chinese medicine for thousands of years
helping debilitated patients recover from illness.

Although written record of Cordyceps sinensis use
appeared in Traditional Chinese Medicine centuries ago, it wasn’t really
noticed in the West until recently. The last two decades have seen a great
increase in research on cordyceps as a medicinal mushroom.

There
are many reported cordyceps health benefits.
 Some of these include:

·         Cholesterol reduction

·         Stimulation of the immune system

·         Faster recovery from bronchitis and respiratory diseases

·         Increased efficiency and stamina of the circulatory system

·         Anti-tumor properties

·         Liver protection and enhanced recovery from chemotherapy

·         Sexual issues make active strongly and long timing

·         A general body adaptogen, resulting in more energy, strength, and
stamina
 the reasons behind some
of these benefits are still not fully understood. Yet research has found some
promising proof behind cordyceps claims. A few of the helpful constituents
found are:

Sterols – Alcohols of the steroid group. Believed to lower
cholesterol, reduce the risk of heart disease, and possibly have some
anti-tumor properties.

Polysaccharides – Complex carbohydrates made up of chains of
sugars. Known to stabilize blood pressure, have an effect on free radicals, and
stimulate the immune system.

Nucleosides – Organic molecules that are the converted into
building blocks of the genetic material DNA and RNA. Nucleoside drugs are
sometimes used to treat cancer.  

One of the most useful things that Cordyceps sinensis appears
to do is the simple act of oxygenation. The fungus dilates the
airways in the lungs, resulting in more oxygen to the blood. Thus, more oxygen
reaches every cell of the body, resulting in better cell function and greater
energy levels.

Cordyceps is used therapeutically
for asthma, bronchitis, chemoprotection, exercise performance, hepatitis
B, hepatic cirrhosis, hyperlipidemia (high cholesterol), as an
immunosuppressive agent, and in chronic renal failure.

The fungus became popular in 1993 when two female Chinese
athletes, who admitted using cordyceps supplements, beat the world records in
the track and field competition at the Stuttgart World Championships for the
1,500-, 3,000-, and 10,000-meter runs. The women were drug tested for any
banned substances such as steroids and were negative. Their coach attributed
the performance to the cordyceps supplementation.

POTENTIAL
HEALTH BENEFITS OF CORDYCEPS

Hepatitis B:

Cordyceps may stimulate the immune system and improve serum gamma
globulin levels in hepatitis B patients. Currently, there is insufficient
evidence to recommend for or against the use of cordyceps for chronic hepatitis
B. However, the results are promising. Additional study of cordyceps and
current hepatitis treatments is needed. 

Hyperlipidemia
(high cholesterol):

Cordyceps may lower total cholesterol and triglyceride, although
these changes may not be permanent or long lasting. Longer studies with follow
up are needed to determine the long-term effects of cordyceps on
hyperlipidemia. 

Anti-aging:

Cordyceps may improve various symptoms related to aging. However,
higher quality studies testing specific symptoms of aging are needed before the
effects of cordyceps can be described. Currently, there is insufficient
evidence to recommend for or against the use of cordyceps for anti-aging. 

Asthma:

Cordyceps may reduce some asthma symptoms. Additional studies are
needed to make a firm recommendation. 

Bronchitis:

There is insufficient evidence from controlled clinical trials to
recommend for or against the use of cordyceps for bronchitis. Most studies
using cordyceps have found improved symptoms with cordyceps more than the
control drugs. Although results are promising, more studies should be performed
before a firm recommendation can be made. 

Chemoprotective:

There is insufficient evidence to recommend for or against the use
of cordyceps as a chemoprotective agent in aminoglycoside toxicity.
However, the results are promising. 

Exercise
performance enhancement
:

In 1993, two female Chinese athletes, who admitted using cordyceps
supplements, beat the world records in the track and field competition at the
Stuttgart World Championships for the 1,500-, 3,000-, and 10,000-meter runs.
However, there is insufficient evidence from conflicting controlled clinical
trials to recommend for or against the use of cordyceps for improving exercise
performance. More studies are needed in this area. 

Immunosuppression:

Two studies using combination herbal treatments that included
cordyceps indicate that these combinations suppressed the immune system
in kidney transplant and lupus nephritis patients. However, as
these treatments used combination products, the effect of cordyceps cannot be
defined. More studies with cordyceps as a monotherapy are needed. 

Liver
disease (hepatic cirrhosis)
:

In traditional Chinese medicine, cordyceps has been used to
support and improve liver function. In two studies using herbal combinations
that included cordyceps, liver function improved liver and immune function.
However, as these studies used combination treatments, the effect of cordyceps
alone is unknown. 

Renal
failure (chronic)
:

In traditional Chinese medicine, cordyceps is used to strengthen
kidney function. Two studies indicate that cordyceps may improve renal function
in patients with chronic renal failure. More studies are needed to confirm
these findings. 

Diabetes. Cordyceps may benefit people at risk of diabetes. Researchers from
University of Macau, China, isolated a

polysaccharide of molecular weight approximately 210kDa was isolated from cultured
Cordyceps mycelia. This isolated polysaccharides, CSP-1, has a strong
antidant activity and a hypoglycemic effect on normal and alloxan-diabetic
mice and streptozotocin (STZ)-diabetic rats. When administered at a dose
of higher than 200mg/kg body wt. daily for 7 days, CSP-1 produced a
significant drop in blood glucose level in both STZ-induced diabetic rats and
alloxan-induced diabetic mice.

Researchers from China Agricultural University, Beijing, also
noticed the blood glucose lowering effects of a polysaccharide extracted
from the fruting bodies and mycelia of Cordyceps militaris in a study of rats.
The hypoglycemic effect of this polysaccharide-enriched Cordyceps
militaris extract was dose-dependent. Korean researchers showed a
water-extract of Cordyceps militaris ameliorated insulin resistance by
enhancing glucose utilization in skeletal muscles of rats.

Anti-oxidative
Activities
 Cordyceps has antioxidant activities. Researchers from Chia Nan
University of Pharmacy and Science,

Taiwan, demonstrated the protective effects of cultured Cordyceps militaris and
natural Cordyceps sinensis against oxidative damage of biomolecules in a
vitro study. They both have free radical scavenging abilities.

Cancer Cordyceps may offer benefits to
those suffered from certain cancers. The aqueous extract of Cordyceps sinensis
(Cs), one of the traditional Chinese medicines, has been demonstrated to
benefit a wide range of disorders in either animal or test-tube studies.
Here are some most recent animal or in vitro studies suggesting its benefits in
cancers.

Korean researchers reported cytotoxic effects of cultivated
fruiting bodies of Cordyceps militaris extracts against the proliferation
of the human premyelocytic leukemia cell HL-60 via the activation of caspase-3.

Researchers from Nanjing University shouls that a polysaccharide
extracted from a cultivated Cordyceps sinensis fungus significantly
enhanced superoxide dismutase activity of liver, brain and serum as well as
glutathione peroxidase activity of liver and brain in tumor-bearing mice.
It also inhibited H22 tumor growth in the mice.

Hong Kong researchers demonstrated that an
ethanol 
extract of
cultivated mycelium of a Cordyceps sinensis fungal mycelium has strong
anti-tumor activity on four cancer cell lines MCF-7 breast cancer, B16 mouse
melanoma, HL-60 human premyelocytic leukemia and HepG2 human
hepatocellular carcinoma. In an animal test, the EtOAc extract showed
significant inhibiting effect on B16-induced melanoma in C57BL/6 mice, causing
about 60% decrease of tumor size over 27 days. In contrast, this extract
had much lower cytotoxicity against normal mouse bone marrow cells.

Cordyceps sinensis is believed to be an immunomodulator. Hong
Kong researchers demonstrated that a cultivated strain of Cordyceps sinensis
induced the production of interleukin (IL)-1beta, IL-6, IL-10 and tumor
necrosis factor alphaalpha from PBMC, augmented surface expression of CD25 on
lymphocytes in a vitro study. While, researchers from Zhejiang University,
China, desmonstrated increased ovalbumin-specific IgG, IgG1 and IgG2b serum
levels after treating the mice with edible mycelia of Cordyceps sinensis.

A rat study has shown that a Cordyceps sinensis mycelium extract
protected mice from group A streptococcal infection. It increased IL-12
and IFN-gamma expression and macrophage phagocytic activities.

Memory Cordyceps may benefit people
suffered from memory deficits. The extract of Cordyceps ophioglossoides
protected the Abeta-induced neuronal cell death and memory loss through
free radical scavenging activity.

Cholesterol
Profiles

Cordyceps may benefit people with cholesterol-lowering effects. In
a study, researchers fed mice with cholesterol-

enriched diet. They found that the serum total cholesterol (TC) of all mice
groups administered Cordyceps sinensis

extracts with the cholesterol-enriched diet decreased more than in the control
group. 

Heart
and Circulation Issues
 Cordyceps may offer benefits of cardiovascular protection.
Extracts of the fruiting bodies of cultured Cordyceps sinensis has been
shown to exert beneficial effects on the formation of the atherosclerotic
lesion induced by oxidative stress with few side effects in a study of
mice. In the study, researchers fed mice with an atherogenic diet and treated
with the extracts for 12 weeks. Mice fed the atherogenic diet showed
marked increases in serum lipid and lipid peroxide levels and also aortic
cholesterol levels, particularly cholesteryl ester level, a major lipid
constituent in atherosclerotic lesions. According to the authors, the
extracts significantly suppressed the increased serum lipid peroxide level but
not other lipid levels in a dose-dependent manner. WECS also suppressed
the increased aortic cholesteryl ester level in a dose-dependent manner. 









































































































Researchers isolated a macromolecule from Cordyceps sinensis and
they found this molecule has blood pressure lowering and vaso-relaxing
effects. The researchers explained that the vasorelaxation was mediated by the
endothelium possibly by stimulating the release of the nitric oxide and
endothelium-derived hyperpolarizing factor.



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